Convalescent plasma therapy, a century-old medical remedy, is being revisited as a viable and immediate option for mitigating the impact of SARS-CoV Current Issue July In this Pearls article, Philipp Brandt, Enrico Garbe and Slavena Vylkova present an overview of the metabolome analyses in human pathogenic fungi to date. They provide examples of new discoveries made by such approaches, and discuss future research directions. CPA complicates previously treated TB due to the residual structural lesions. Bongomin discusses prevalence, misdiagnosis and treatment of the condition in patients previously treated for pulmonary TB. Tumor suppressors can exert pro-proliferation functions in specific contexts. Romero-Medina and Venuti et al show that beta HPV38 can convert p53 functions from a tumor suppressor to an oncoprotein via the formation of a transcriptionally repressive complex. Antoni and Quentin et al use single-particle electron cryo microscopy to determine structures of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state.
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Here, we describe the origins and evolution of these viruses, and the circumstances that led to the AIDS pandemic. Both HIVs are the result of multiple cross-species transmissions of simian immunodeficiency viruses SIVs naturally infecting African primates. Most of these transfers resulted in viruses that spread in humans to only a limited extent. Tracing the genetic changes that occurred as SIVs crossed from monkeys to apes and from apes to humans provides a new framework to examine the requirements of successful host switches and to gauge future zoonotic risk.
Acquired Immune Deficiency Syndrome AIDS was first recognized as a new disease in when increasing numbers of young homosexual men succumbed to unusual opportunistic infections and rare malignancies CDC ; Greene A retrovirus, now termed human immunodeficiency virus type 1 HIV-1 , was subsequently identified as the causative agent of what has since become one of the most devastating infectious diseases to have emerged in recent history Barre-Sinoussi et al.
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Origins of HIV and the AIDS Pandemic
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